Apple released a game porting toolkit that has been improved by Whisky:

app that wraps both Wine, the tool that translates Windows API calls to their Unix-like equivalents, and Appleโ€™s game porting toolkit into one very friendly interface. That removes pretty much all of the work out of the process, to the point where all I had to do was download Whisky and drag it into my Applications folder.

Dan Moren writes at Six Colors that maybe Apple should make running PC games on MacOS great with this method.